Toggle Main Menu Toggle Search

Open Access padlockePrints

Mild Cognitive Impairment in Rural Tanzania: Prevalence, Profile, and Outcomes at 4-Year Follow-up

Lookup NU author(s): Dr Stella Paddick, Dr Catherine Dotchin, Dr Andrew Teodorczuk, Professor Richard Walker


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Objective: Mild cognitive impairment (MCI) is recognized as a high-risk condition for conversion to dementia, although data on outcomes of MCI in sub-Saharan Africa are scarce. We investigated outcomes of MCI over a 4-year period in Tanzania and considered risk factors for conversion to dementia. Methods: In a longitudinal cohort study in the Hai district, Tanzania, patients with MCI were identified during a two-phase prevalence study carried out in 2010. Of 1,198 people aged 70 years and over screened in phase I, a stratified sample of 296 were fully assessed in phase II. MCI was defined according to international consensus criteria. DSM-IV criteria were used for dementia diagnosis. Background demographic and risk factor data were collected, and neuropsychiatric symptoms were assessed using the neuropsychiatric inventory. Patients were followed-up in 2011, 2012 and 2014. Results: Forty-six MCI patients were identified. After adjusting for stratification, the crude prevalence of MCI was 7.0% (95% CI: 3.6-10.4). Over a 4-year period, 15 patients (32.6%) progressed to dementia, 2 patients (4.3%) returned to normal cognition, 1 developed late-onset schizophrenia, 8 patients (17.4%) had stable MCI, 19 patients (41.3%) died, and 1 refused assessment. Age, sex, education levels, body mass index, hypertension, and comorbidity were not associated with progression to dementia. Conclusion: In this rural Tanzanian population, rates of conversion from MCI to DSM-IV dementia were similar to those reported in high-income countries. Over a third of all patients had died at the 4-year follow-up.

Publication metadata

Author(s): Paddick SM, Kisoli A, Samuel M, Higginson J, Gray WK, Dotchin CL, Longdon AR, Teodorczuk A, Chaote P, Walker RW

Publication type: Article

Publication status: Published

Journal: American Journal of Geriatric Psychiatry

Year: 2015

Volume: 23

Issue: 9

Pages: 950-959

Print publication date: 01/09/2015

Online publication date: 11/12/2014

Acceptance date: 05/12/2014

ISSN (print): 1064-7481

ISSN (electronic): 1545-7214

Publisher: Elsevier


DOI: 10.1016/j.jagp.2014.12.005


Altmetrics provided by Altmetric