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Methods to determine the interactions of micro- and nanoparticles with mucus

Lookup NU author(s): Professor Jeffrey Pearson


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The present review provides an overview of methods and techniques for studying interactions of micro- and nanoparticulate drug delivery system with mucus. Nanocarriers trapped by mucus are featuring a change in particle size and zeta potential that can be utilized to predict their mucus permeation behavior. Furthermore, interactions between nanoparticulate drug delivery systems and mucus layer modify the viscoelasticity of mucus which can be detected via rheological studies and quartz crystal microbalance with dissipation monitoring (QCM-D) analysis. Having a closer look at molecular interactions between drug carrier and mucus small-angle neutron scattering (SANS) is an appropriate analysis technique. Moreover, different methods to determine particle diffusion in mucus such as the newly established Transwell diffusion system, rotating silicone tube technique, multiple-particle tracking (MPT) and diffusion NMR are summarized within this review. The explanations and discussed pros and cons of collated methods and techniques should provide a good starting point for all those looking forward to move in this interesting field. (C) 2015 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Griessinger J, Dunnhaupt S, Cattoz B, Griffiths P, Oh S, Gomez SBI, Wilcox M, Pearson J, Gumbleton M, Abdulkarim M, de Sousa IP, Bernkop-Schnurch A

Publication type: Review

Publication status: Published

Journal: European Journal of Pharmaceutics and Biopharmaceutics

Year: 2015

Volume: 96

Pages: 464-476

Print publication date: 01/10/2015

Online publication date: 29/01/2015

Acceptance date: 07/01/2015

ISSN (print): 0939-6411

ISSN (electronic): 1873-3441



DOI: 10.1016/j.ejpb.2015.01.005