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Lookup NU author(s): Professor Jeffrey Pearson
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The present review provides an overview of methods and techniques for studying interactions of micro- and nanoparticulate drug delivery system with mucus. Nanocarriers trapped by mucus are featuring a change in particle size and zeta potential that can be utilized to predict their mucus permeation behavior. Furthermore, interactions between nanoparticulate drug delivery systems and mucus layer modify the viscoelasticity of mucus which can be detected via rheological studies and quartz crystal microbalance with dissipation monitoring (QCM-D) analysis. Having a closer look at molecular interactions between drug carrier and mucus small-angle neutron scattering (SANS) is an appropriate analysis technique. Moreover, different methods to determine particle diffusion in mucus such as the newly established Transwell diffusion system, rotating silicone tube technique, multiple-particle tracking (MPT) and diffusion NMR are summarized within this review. The explanations and discussed pros and cons of collated methods and techniques should provide a good starting point for all those looking forward to move in this interesting field. (C) 2015 Elsevier B.V. All rights reserved.
Author(s): Griessinger J, Dunnhaupt S, Cattoz B, Griffiths P, Oh S, Gomez SBI, Wilcox M, Pearson J, Gumbleton M, Abdulkarim M, de Sousa IP, Bernkop-Schnurch A
Publication type: Review
Publication status: Published
Journal: European Journal of Pharmaceutics and Biopharmaceutics
Print publication date: 01/10/2015
Online publication date: 29/01/2015
Acceptance date: 07/01/2015
ISSN (print): 0939-6411
ISSN (electronic): 1873-3441
Publisher: ELSEVIER SCIENCE BV