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Hyperglycaemia per se does not affect erythrocyte glucose-6-phosphate dehydrogenase activity in ketosis-prone diabetes

Lookup NU author(s): Dr Eugene Sobngwi


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Aim. - Previously, we described patients with ketosis-prone type 2 diabetes (KPD) and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but no mutation of the G6PD gene. Our present study used two complementary approaches to test whether hyperglycaemia might inhibit G6PD activity: (1) effect of acute hyperglycaemia induced by glucose ramping; and (2) effect of chronic hyperglycaemia using correlation between G6PD activity and HbA(1c) levels.Methods. - In the first substudy, 16 KPD patients were compared with 11 healthy, non-diabetic control subjects of the same geographical background. Erythrocyte G6PD activity and plasma glucose were assessed at baseline and every 40 min during intravenous glucose ramping that allowed maintaining hyperglycaemia for more than 3 h. In the second substudy, erythrocyte G6PD activity and HbA(1c) levels were evaluated in 108 consecutive African patients with either type 2 diabetes or KPD, and a potential correlation sought between the two variables.Results. - The maximum plasma glucose level after 200 min of glucose perfusion was 20.9 +/- 3.7 mmol/L for patients and 10.7 +/- 2.3 mmol/L for controls. There was no difference between baseline and repeated G6PD activity levels during acute hyperglycaemia in either KPD patients (P = 0.94) or controls (P = 0.57), nor was there any significant correlation between residual erythrocyte G6PD activity and HbA(1c) levels (r = -0.085, P = 0.38).Conclusion. - Neither acute nor chronic hyperglycaemia affects erythrocyte G6PD activity. Thus, hyperglycaemia alone does not explain cases of G6PD deficiency in the absence of gene mutation as described earlier. (C) 2014 Elsevier Masson SAS. All rights reserved.

Publication metadata

Author(s): Choukem SP, Sobngwi E, Garnier JP, Letellier S, Mauvais-Jarvis F, Calvo F, Gautier JF

Publication type: Article

Publication status: Published

Journal: Diabetes & Metabolism

Year: 2015

Volume: 41

Issue: 4

Pages: 326-330

Print publication date: 01/09/2015

Online publication date: 01/09/2015

Acceptance date: 15/07/2014

ISSN (print): 1262-3636

ISSN (electronic): 1878-1780

Publisher: Elsevier Masson


DOI: 10.1016/j.diabet.2014.07.002


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Funder referenceFunder name
Francophone Diabetes Society (SFD)
French Diabetes Association (AFD)
PHRC AOR 02 088institutional grant from Assistance Publique-Hopitaux de Paris