Toggle Main Menu Toggle Search

Open Access padlockePrints

A data repository and analysis framework for spontaneous neural activity recordings in developing retina

Lookup NU author(s): Dr Jennifer Simonotto, Professor Evelyne SernagorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Background: During early development, neural circuits fire spontaneously, generating activity episodes with complex spatiotemporal patterns. Recordings of spontaneous activity have been made in many parts of the nervous system over the last 25 years, reporting developmental changes in activity patterns and the effects of various genetic perturbations.Results: We present a curated repository of multielectrode array recordings of spontaneous activity in developing mouse and ferret retina. The data have been annotated with minimal metadata and converted into HDF5. This paper describes the structure of the data, along with examples of reproducible research using these data files. We also demonstrate how these data can be analysed in the CARMEN workflow system. This article is written as a literate programming document; all programs and data described here are freely available.Conclusions: 1. We hope this repository will lead to novel analysis of spontaneous activity recorded in different laboratories. 2. We encourage published data to be added to the repository. 3. This repository serves as an example of how multielectrode array recordings can be stored for long-term reuse.

Publication metadata

Author(s): Eglen SJ, Weeks M, Jessop M, Simonotto J, Jackson T, Sernagor E

Publication type: Article

Publication status: Published

Journal: GigaScience

Year: 2014

Volume: 3

Online publication date: 26/03/2014

Acceptance date: 13/03/2014

Date deposited: 06/04/2016

ISSN (electronic): 2047-217X

Publisher: BioMed Central Ltd


DOI: 10.1186/2047-217X-3-3


Altmetrics provided by Altmetric


Funder referenceFunder name
083205/B/07/ZWellcome Trust