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Lookup NU author(s): Dr Angela Pyle, Haidyan Anugrha, Dr Marzena Kurzawa-Akanbi, Professor Alison Yarnall, Professor David BurnORCiD, Professor Gavin Hudson
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Like any organ, the brain is susceptible to the march of time and a reduction in mitochondrial biogenesis is a hallmark of the aging process. In the largest investigation of mitochondrial copy number in Parkinson's disease (PD) to date and by using multiple tissues, we demonstrate that reduced Parkinson DNA (mitochondrial DNA mtDNA) copy number is a biomarker for the etiology of PD. We used established methods of mtDNA quantification to assess the copy number of mtDNA in n = 363 peripheral blood samples, n = 151 substantia nigra pars compacta tissue samples and n = 120 frontal cortex tissue samples from community-based PD cases fulfilling UK-PD Society brain bank criteria for the diagnosis of PD. Accepting technical limitations, our data show that PD patients suffer a significant reduction in mtDNA copy number in both peripheral blood and the vulnerable substantia nigra pars compacta when compared to matched controls. Our study indicates that reduced mtDNA copy number is restricted to the affected brain tissue, but is also reflected in the peripheral blood, suggesting that mtDNA copy number may be a viable diagnostic predictor of PD. (C) 2016 The Authors. Published by Elsevier Inc.
Author(s): Pyle A, Anugrha H, Kurzawa-Akanbi M, Yarnall A, Burn D, Hudson G
Publication type: Article
Publication status: Published
Journal: Neurobiology of Aging
Year: 2016
Volume: 38
Pages: 216.e7–216.e10
Print publication date: 01/02/2016
Online publication date: 05/11/2015
Acceptance date: 29/10/2015
ISSN (print): 0197-4580
ISSN (electronic): 1558-1497
Publisher: Elsevier Science
URL: http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.033
DOI: 10.1016/j.neurobiolaging.2015.10.033
PubMed id: 26639155
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