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Lookup NU author(s): Professor John O'Brien, Professor Alan ThomasORCiD
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Vascular dementia is one of the most common causes of dementia after Alzheimer's disease, causing around 15% of cases. However, unlike Alzheimer's disease, there are no licensed treatments for vascular dementia. Progress in the specialty has been difficult because of uncertainties over disease classification and diagnostic criteria, controversy over the exact nature of the relation between cerebrovascular pathology and cognitive impairment, and the paucity of identifiable tractable treatment targets. Although there is an established relation between vascular and degenerative Alzheimer's pathology, the mechanistic link between the two has not yet been identified. This Series paper critiques some of the key areas and controversies, summarises treatment trials so far, and makes suggestions for what progress is needed to advance our understanding of pathogenesis and thus maximise opportunities for the search for new and effective management approaches.
Author(s): O'Brien JT, Thomas A
Publication type: Article
Publication status: Published
Journal: The Lancet
Year: 2015
Volume: 386
Issue: 10004
Pages: 1698-1706
Print publication date: 24/10/2015
Acceptance date: 01/01/1900
ISSN (print): 0140-6736
ISSN (electronic): 1474-547X
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/S0140-6736(15)00463-8
DOI: 10.1016/S0140-6736(15)00463-8
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