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Lookup NU author(s): Professor Andrew Gennery,
Dr Jonathan Wallis
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BACKGROUND: ABO-incompatible (ABOi) cardiac transplantation is now used widely in infants with isohemagglutinin titers < 1:4, but there is increasing evidence that ABOi transplantation can also be used in children with significantly higher titers. We reviewed our high-titer ABOi transplants and report our results here.METHODS: Patients who underwent ABOi cardiac transplantation from 2000 to 2013 with pre-existing isohemagglutinin titers of >= 1:16 were identified from departmental databases. Outcomes were reviewed using medical and laboratory records.RESULTS: Thirty patients underwent ABOi cardiac transplantation between 2000 and 2013. Twelve (40%) had pre-transplant isohemagglutinin titers of >= 1:16 and were included for further study. Median age was 14.9 (range 9.8 to 107.3) months and median weight was 9.6 (range 7.6 to 25) kg. Five (42%) were male. Pre-transplant diagnosis was cardiomyopathy in 8 of 12 (67%) and congenital heart disease in 4 of 12 (33%). Highest pre-transplant isohemagglutinin titer was 1:256 in 2 patients. Four patients (33%) had early antibody-mediated rejection (AMR), all within 15 days post-transplant. Management included use of rituximab, bortezomib, immunoadsorption and eculizumab. Three patients died but no deaths were associated with high isohemagglutinin titers.CONCLUSIONS: ABOi cardiac transplantation in patients with isohemagglutinin titers >= 1:16 is possible. AMR may occur early and immunoadsorption has proven effective at decreasing antibody titers. (C) 2015 International Society for Heart and Lung Transplantation. All rights reserved.
Author(s): Irving CA, Gennery AR, Carter V, Wallis JP, Hasan A, Griselli M, Kirk R
Publication type: Article
Publication status: Published
Journal: Journal of Heart and Lung Transplantation
Print publication date: 01/08/2015
Online publication date: 26/03/2015
Acceptance date: 01/01/1900
ISSN (print): 1053-2498
ISSN (electronic): 1557-3117
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