Toggle Main Menu Toggle Search

Open Access padlockePrints

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lookup NU author(s): Laura Pascoe

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.


Publication metadata

Author(s): Lu YC, Day FR, Gustafsson S, Buchkovich ML, Na JB, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman AK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S, Lagou V, Li R, Li X, Locke A, Lu C, Magi R, Perry JRB, Pers TH, Qi QB, Sanna M, Schmidt EM, Scott WR, Shungin D, Teumer A, Vinkhuyzen AAE, Walker RW, Westra HJ, Zhang MF, Zhang WH, Zhao JH, Zhu ZH, Afzal U, Ahluwalia TS, Bakker SJL, Bellis C, Bonnefond A, Borodulin K, Buchman AS, Cederholm T, Choh AC, Choi HJ, Curran JE, de Groot LCPGM, De Jager PL, Dhonukshe-Rutten RAM, Enneman AW, Eury E, Evans DS, Forsen T, Friedrich N, Fumeron F, Garcia ME, Gartner S, Han BG, Havulinna AS, Hayward C, Hernandez D, Hillege H, Ittermann T, Kent JW, Kolcic I, Laatikainen T, Lahti J, Leach IM, Lee CG, Lee JY, Liu T, Liu YF, Lobbens S, Loh M, Lyytikainen LP, Medina-Gomez C, Michaelsson K, Nalls MA, Nielson CM, Oozageer L, Pascoe L, Paternoster L, Polasek O, Ripatti S, Sarzynski MA, Shin CS, Narancic NS, Spira D, Srikanth P, Steinhagen-Thiessen E, Sung YJ, Swart KMA, Taittonen L, Tanaka T, Tikkanen E, van der Velde N, van Schoor NM, Verweij N, Wright AF, Yu L, Zmuda JM, Eklund N, Forrester T, Grarup N, Jackson AU, Kristiansson K, Kuulasmaa T, Kuusisto J, Lichtner P, Luan JA, Mahajan A, Mannisto S, Palmer CD, Ried JS, Scott RA, Stancakova A, Wagner PJ, Demirkan A, Doring A, Gudnason V, Kiel DP, Kuhnel B, Mangino M, Mcknight B, Menni C, O'Connell JR, Oostra BA, Shuldiner AR, Song KJ, Vandenput L, van Duijn CM, Vollenweider P, White CC, Boehnke M, Boettcher Y, Cooper RS, Forouhi NG, Gieger C, Grallert H, Hingorani A, Jorgensen T, Jousilahti P, Kivimaki M, Kumari M, Laakso M, Langenberg C, Linneberg A, Luke A, Mckenzie CA, Palotie A, Pedersen O, Peters A, Strauch K, Tayo BO, Wareham NJ, Bennett DA, Bertram L, Blangero J, Bluher M, Bouchard C, Campbell H, Cho NH, Cummings SR, Czerwinski SA, Demuth I, Eckardt R, Eriksson JG, Ferrucci L, Franco OH, Froguel P, Gansevoort RT, Hansen T, Harris TB, Hastie N, Heliovaara M, Hofman A, Jordan JM, Jula A, Kahonen M, Kajantie E, Knekt PB, Koskinen S, Kovacs P, Lehtimaki T, Lind L, Liu YM, Orwoll ES, Osmond C, Perola M, Perusse L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Rivadeneira F, Rudan I, Salomaa V, Sorensen TIA, Stumvoll M, Tonjes A, Towne B, Tranah GJ, Tremblay A, Uitterlinden AG, van der Harst P, Vartiainen E, Viikari JS, Vitart V, Vohl MC, Volzke H, Walker M, Wallaschofski H, Wild S, Wilson JF, Yengo L, Bishop DT, Borecki IB, Chambers JC, Cupples LA, Dehghan A, Deloukas P, Fatemifar G, Fox C, Furey TS, Franke L, Han JL, Hunter DJ, Karjalainen J, Karpe F, Kaplan RC, Kooner JS, McCarthy MI, Murabito JM, Morris AP, Bishop JAN, North KE, Ohlsson C, Ong KK, Prokopenko I, Richards JB, Schadt EE, Spector TD, Widen E, Willer CJ, Yang J, Ingelsson E, Mohlke KL, Hirschhorn JN, Pospisilik JA, Zillikens MC, Lindgren C, Kilpelainen TO, Loos RJF

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2016

Volume: 7

Print publication date: 01/02/2016

Online publication date: 01/02/2016

Acceptance date: 16/12/2015

Date deposited: 25/04/2016

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ncomms10495

DOI: 10.1038/ncomms10495


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Aase and Ejner Danielsens Foundation
Agency for Health Care Policy Research
Ahokas Foundation
ALFEDIAM
Althingi (the Icelandic Parliament)
ANR ('Agence Nationale de la 359 Recherche')
Ardix Medical
AstraZeneca
Australian Research Council
Boston University School of Medicine
Cancer Research UK
Centers for Disease Control and Prevention/Association of Schools of Public Health
Chief Scientist Office of the Scottish Government
CMSB
Deutsche Forschungsgemeinschaft
DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland)
Dutch Dairy Association (NZO)
Dutch Kidney Foundation
Emil Aaltonen Foundation
ENGAGE consortium
Erasmus University
Estonian Government
European Union framework program 6 EUROSPAN project
Finnish Cardiovascular Research Foundation
Finnish Cultural Foundation
Finnish Diabetes Research Foundation
Finska Lakaresallskapet
Folkhalsan Research Foundation
German Bundesministerium fuer Forschung und Technology
German Diabetes Association
German Research Council
GlaxoSmithKline
Goran Gustafsson Foundation
Hjartavernd (the Icelandic Heart Association)
INSERM (Reseaux en Sante Publique, Interactions entre les determinants de la sante)
Integrated Research and Treatment Centre (IFB)
John D and Catherine T MacArthur Foundation Research Networks
Kuopio University Hospital Medical Fund
La Fondation de France
Liv och Halsa
Ludwig-Maximilians-Universitat
Lundberg Foundation
Ministry of Economic Affairs, Agriculture and Innovation, The Netherlands
MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE)
MRC Human Genetics Unit
MRC-GlaxoSmithKline
Munich Center of Health Sciences (MC Health)
Municipality of Rotterdam
National Center for Advancing Translational Sciences
National Heart Lung and Blood Institute (NHLBI)
National Heart, Lung and Blood Institute's Framingham Heart Study
National Institute for Health Research (NIHR)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Netherlands Consortium Healthy Ageing (NCHA)
Netherlands Genomics Initiative (NGI)
Novo Nordisk
ONIVINS
Paavo Nurmi Foundation
Pierre Fabre
Roche
Russian Foundation for Basic Research
Samfundet Folkhalsan
Swedish Diabetes Foundation
Swedish Heart-Lung Foundation
Swedish Research Council for Infrastructures
Tampere Tuberculosis Foundation
Tampere University Hospital Medical Fund
Topcon
Torsten and Ragnar Soderberg's Foundation
Translational Genomics Research Institute
Turku University Hospital Medical Fund
University of Maryland General Clinical Research Center
Uppsala University
Uppsala University Hospital
VA Clinical Science Research and Development
VU University Medical Center; Wageningen University
Wellcome Trust
Academy of Finland
ALK-Abello A/S (Horsholm, Denmark)
American Heart Association
Arthritis Research UK
Association Diabete Risque Vasculaire, the Federation Francaise de Cardiologie
Bayer Diagnostics
BBSRC
Becton Dickinson
BMBF (DEEP)
Boehringer Ingelheim Foundation
British Heart Foundation
British Skin Foundation
Canadian Institutes of Health Research
Cardionics
Cohortes Sante TGIR
CPER ('Contrat de Projets Etat-Region')
Danish Agency for Science, Technology and Innovation
Danish Council for Independent Research
Danish Medical Research Council
Department of Health, UK
Diabetes UK
Dutch Inter University Cardiology Institute Netherlands (ICIN)
Erasmus Medical Center
European Commission
European Community's Seventh Framework Programme
European Research Council
European Union
European Union (EU_FP7_NoE 'Epigenesys')
Faculty of Biology and Medicine of Lausanne
Federal Ministry of Education and Research (German Obesity Biomaterial Bank)
Federal State of Mecklenburg-West Pomerania
Finnish Centre for Pensions
Finnish Diabetes Research Society
Finnish Foundation for Cardiovascular Research
Finnish Foundation for Pediatric Research
Finnish Special Governmental Subsidy for Health Sciences
Food Standards Agency, UK
German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF)
Health and Safety Executive, UK
Helmholtz Zentrum Munchen-German Research Center for Environmental Health
Illinois Department of Public Health
John W. Barton Sr Chair in Genetics and Nutrition
Juho Vainio Foundation
King's College London
Knut och Alice Wallenberg Foundation
Kompetenznetz Adipositas
Kuopio University Hospital
Li Ka Shing Foundation
Local Government Pensions Institution (KEVA)
Lundbeck Foundation
Max-Planck Institute
Medical Research Council, UK
MEKOS Laboratories Denmark
Merck Sante
Ministry for Health, Welfare and Sports, The Netherlands
Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania
Ministry of Education, Culture and Science, The Netherlands
Ministry of Science, Education and Sport of the Republic of Croatia
National Center for Advancing Translational Sciences, CTSI
National Center for Research Resources (NCRR)
National Genome Research Institute, Korean Center for Disease Control and Prevention
National Institute for Health and Welfare (THL)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC)
National Institute on Aging (NIA)
Netherlands Heart Foundation
Netherlands Organisation for Scientific Research (NWO)
Netherlands Organization for the Health Research and Development (ZonMw)
Novo Nordisk Foundation
Orion-Farmos Research Foundation
Research Centre for Prevention and Health, the Capital Region of Denmark
Research Institute for Diseases in the Elderly (RIDE)
Research into Ageing, UK
Royal Swedish Academy of Science
Sanger Institute
SFD ('Societe Francophone du 358 Diabete')
Siemens Healthcare
Signe and Ane Gyllenberg Foundation
Sigrid Juselius Foundation
Social Insurance Institution of Finland (KELA)
State of Bavaria
Stroke Association, UK
Swedish Foundation for Strategic Research
Swedish Research Council
Swiss National Science Foundation
Sylvia AMP; Charles Viertel Charitable Foundation
Timber Merchant Vilhelm Bangs Foundation
Unilever UK
University Cancer Research Fund at UNC Chapel Hill
University of Eastern Finland
USDA National Institute of Food and Agriculture
Velux Foundation
ERC-StG-281641European Research Council
SFB992Deutshe Forschungsgemeinschaft

Share