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Pathways mediating functional recovery

Lookup NU author(s): Professor Stuart BakerORCiD, Dr Boubker Zaaimi, Dr Karen Fisher, Dr Demetris Soteropoulos


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Following damage to the motor system (e.g., after stroke or spinal cord injury), recovery of upper limb function exploits the multiple pathways which allow motor commands to be sent to the spinal cord. Corticospinal fibers originate from premotor as well as primary motor cortex. While some corticospinal fibers make direct monosynaptic connections to motoneurons, there are also many connections to interneurons which allow control of motoneurons indirectly. Such interneurons may be placed within the cervical enlargement, or more rostrally (propriospinal interneurons). In addition, connections from cortex to the reticular formation in the brainstem allow motor commands to be sent over the reticulospinal tract to these spinal centers. In this review, we consider the relative roles of these different routes for the control of hand function, both in healthy primates and after recovery from lesion.

Publication metadata

Author(s): Baker SN, Zaaimi B, Fisher KM, Edgley SA, Soteropoulos DS

Publication type: Review

Publication status: Published

Journal: Progress in Brain Research

Year: 2015

Volume: 218

Pages: 389-412

Online publication date: 19/03/2015

Acceptance date: 01/01/1900

ISSN (print): 0079-6123

ISSN (electronic): 1875-7855



DOI: 10.1016/bs.pbr.2014.12.010