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Eculizumab in children with hemolytic uremic syndrome

Lookup NU author(s): Professor David KavanaghORCiD, Dr Kate Smith-Jackson



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Greenbaum et al. report the first prospective trial of eculizumab in pediatric atypical hemolytic uremic syndrome. As in adult trials, eculizumab appears effective and no serious safety signals were reported. There is the first suggestion of a dichotomy in response to treatment with a trend toward poorer outcome in those without complement abnormalities. This group, however, had worse renal function at presentation, and it remains to be seen whether this represents true non-response or merely late presentation. (C) 2016 International Society of Nephrology

Publication metadata

Author(s): Kavanagh D, Smith-Jackson K

Publication type: Editorial

Publication status: Published

Journal: Kidney International

Year: 2016

Volume: 89

Issue: 3

Pages: 537-538

Print publication date: 01/03/2016

Online publication date: 13/02/2016

Acceptance date: 01/01/1900

ISSN (print): 0085-2538

ISSN (electronic): 1523-1755

Publisher: Elsevier


DOI: 10.1016/j.kint.2015.12.039