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Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia

Lookup NU author(s): Professor Julie Irving

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Abstract

Acute lymphoblastic leukaemia is the most common childhood cancer and for those children who relapse, prognosis is poor and new therapeutic strategies are needed. Recurrent pathways implicated in relapse include RAS, JAK STAT, cell cycle, epigenetic regulation, B cell development, glucocorticoid response, nucleotide metabolism and DNA repair. Targeting these pathways is a rational therapeutic strategy and may deliver novel, targeted therapies into the clinic. Relapse often stems from a minor clone present at diagnosis and thus analysis of persisting leukaemia during upfront therapy may allow targeted drug intervention to prevent relapse.

Publication metadata

Author(s): Irving JAE

Publication type: Review

Publication status: Published

Journal: British Journal of Haematology

Year: 2016

Volume: 172

Issue: 5

Pages: 655-666

Print publication date: 01/03/2016

Online publication date: 16/11/2015

Acceptance date: 01/01/1900

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: WILEY-BLACKWELL

URL: http://dx.doi.org/10.1111/bjh.13852

DOI: 10.1111/bjh.13852

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