Toggle Main Menu Toggle Search

Open Access padlockePrints

Cancer-related symptoms predict psychological wellbeing among prostate cancer survivors: results from the PiCTure study

Lookup NU author(s): Professor Linda Sharp


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


BackgroundProstate cancer treatments are associated with a range of symptoms and physical side-effects. Cancer can also adversely impact on psychological wellbeing. Because many prostate cancer-related symptoms and side-effects are potentially modifiable, we investigated associations between symptoms and psychological wellbeing among prostate cancer survivors.MethodsPostal questionnaires were distributed to men diagnosed with prostate cancer 2-18years previously identified through cancer registries. General and prostate cancer-specific symptoms were assessed using the EORTC QLQ-C30 and QLQ-PR25, with higher symptom scores indicating more/worse symptomatology. Psychological wellbeing was assessed by the DASS-21. Associations between symptoms and each outcome were investigated using multivariate logistic regression, controlling for socio-demographic and clinical factors.ResultsA total 3348 men participated (response rate=54%). Seventeen percent (95%CI 15.2%-17.9%), 16% (95%CI 15.1%-17.8%) and 11% (95%CI 9.5%-11.8%) of survivors scored in the range for depression, anxiety and distress on the DASS scales, respectively. In multivariate models, risk of depression on the DASS scale was significantly higher in men with higher urinary and androgen deprivation therapy (ADT)-related symptoms, and higher scores for fatigue, insomnia and financial difficulties. Risk of anxiety on the DASS scale was higher in men with higher scores for urinary, bowel and ADT-related symptoms and fatigue, dyspnoea and financial difficulties. Risk of distress on the DASS scale was positively associated with urinary, bowel and ADT-related symptoms, fatigue, insomnia and financial difficulties.ConclusionsCancer-related symptoms significantly predict psychological wellbeing among prostate cancer survivors. Greater use of interventions and medications and to alleviate symptoms might improve psychological wellbeing of prostate cancer survivors. Copyright (c) 2015 John Wiley & Sons, Ltd.

Publication metadata

Author(s): Sharp L, O'Leary E, Kinnear H, Gavin A, Drummond FJ

Publication type: Article

Publication status: Published

Journal: Psycho-Oncology

Year: 2016

Volume: 25

Issue: 3

Pages: 282-291

Print publication date: 01/03/2016

Online publication date: 06/08/2015

Acceptance date: 16/06/2014

ISSN (print): 1057-9249

ISSN (electronic): 1099-1611

Publisher: Wiley-Blackwell


DOI: 10.1002/pon.3909


Altmetrics provided by Altmetric


Funder referenceFunder name
Northern Ireland Cancer Registry by the Public Health Agency, Northern Ireland
RoI National Cancer Control Programme
Department of Health
Northern Ireland RD
HRA_HSR/2010/17Health Research Board
NI09-03Prostate Cancer UK
NI-PG13-001Prostate Cancer UK