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Amyloid-beta in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing

Lookup NU author(s): Dr Veronika Boczonadi, Professor Rita HorvathORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


There is increasing evidence that common molecular pathways in neurons are closely linked with mitochondrial function and that mitochondrial dysfunction is connected to various forms of neurodegenerative diseases. For instance, mitochondria are involved in amyloid- (A) deposition in Alzheimer's disease, although the exact molecular pathways remain largely unknown. Brunetti etal () in this issue of EMBO Molecular Medicine provide a novel link between A accumulation and mitochondria. A pathogenic mutation in a Norwegian family inthe mitochondrial metallopeptidase PITRM1 is found to underlie a novel mitochondrial neurodegenerative phenotype associated with A accumulation.

Publication metadata

Author(s): Boczonadi V, Horvath R

Publication type: Editorial

Publication status: Published

Journal: EMBO Molecular Medicine

Year: 2016

Volume: 8

Issue: 3

Pages: 173-175

Print publication date: 01/03/2016

Online publication date: 26/01/2016

Acceptance date: 01/01/1900

ISSN (print): 1757-4676

ISSN (electronic): 1757-4684

Publisher: Wiley-Blackwell


DOI: 10.15252/emmm.201506050