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Anti-mitochondrial protein antibodies in a serum from a patient with systemic lupus erythematosus: Specificity and comparison with other anti-mitochondrial antibodies

Lookup NU author(s): Dr Soren Nielsen

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Abstract

Anti-mitochondrial antibodies present in a serum from a systemic lupus erythematosus patient have been characterized by indirect immunofluorescence of cultured transformed human amnion cells, and by two-dimensional gel electrophoresis and immunoblotting. The antibodies which stained mostly mitochondria in transformed human amnion cells reacted with four mouse brain cortex mitochondrial proteins. These proteins, which have been termed a, b, c and d, exhibited apparent molecular weights of 66 000, 49 000, 49 000 and 44 000, respectively. Proteins a and c exhibited charge variants. Surprisingly, most of the proteins recognized by this serum also reacted with sera from a patient with liver cirrhosis and idiopathic pulmonary fibrosis.

Publication metadata

Author(s): Celis JE, Madsen P, Andersen I, Andersen P, Vayssiere JL, Croizat B, Thiessen H, Nielsen S

Publication type: Article

Publication status: Published

Journal: Electrophoresis

Year: 1987

Volume: 8

Issue: 5

Pages: 238–243

Print publication date: 01/05/1987

Online publication date: 13/04/2005

Acceptance date: 01/01/1987

ISSN (print): 0173-0835

ISSN (electronic): 1522-2683

Publisher: Wiley-VCH Verlag

URL: http://dx.doi.org/10.1002/elps.1150080507

DOI: 10.1002/elps.1150080507

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