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Lookup NU author(s): Dr Soren Nielsen
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Immunofluorescence studies using PCNA autoantibodies specific for the proliferation-sensitive protein cyclin have revealed dramatic changes in the nuclear distribution of this protein during the S-phase of normal and transformed cells. Patterns of cyclin antigen distribution subdivide S-phase and have provided new cell cycle landmarks. Some of these (nucleolar exclusion or staining), mimic topographical patterns of DNA synthesis thus arguing for a role of this protein in some specific aspect of DNA replication.Cells outside S-phase (G0 included) stain only weakly with PCNA antibodies, stressing the usefulness of this reagent for identifying proliferating cells (S-phase cells) of both normal and malignant origins.
Author(s): Celis JE, Madsen P, Nielsen S, Celis A
Publication type: Article
Publication status: Published
Journal: Leukemia Research
Print publication date: 01/02/1986
Online publication date: 22/04/2004
ISSN (print): 0145-2126
ISSN (electronic): 1873-5835
Publisher: Pergamon Press
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