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Anastrozole is a dose-specific superovulator and favors implantation in rats: a prospective study

Lookup NU author(s): Dr Margot Jill Hosie

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Abstract

An alternative superovulator to replace clomiphene citrate (CC) is needed as it is unsuitable for women with polycystic ovarian syndrome and is associated with low pregnancy rates. Anastrozole is an effective superovulator, but has not been well researched. The aim of this study was to determine the optimal dose of anastrozole as a superovulator and ascertain its effects on implantation and uterine ultrastructure during early pregnancy in Wistar rats using scanning electron microscopy. The uterine morphological characteristics which were studied in day 1 and 6 pregnant rats include microvilli density, length, surface "beads", surface glycocalyx, cell borders and apices, uterine surface fording and large surface protrusions. A significant increase in implantation sites is seen in the 15 mg/kg anastrozole group, compared to control. Day 1 and 6 anastrozole groups have similar morphology to the control and different to the CC group. At day 6, large surface protrusions are mostly noted but not limited to anastrozole-treated rats; anastrozole also appears to retain glycocalyx to some extent. The increased number of implantation sites in the 15 mg/kg anastrozole group suggests that this dose superovulates and favors implantation. Anastrozole is probably dose-/species-specific and additionally the surface uterine morphology suggests that anastrozole is implantation friendly.

Publication metadata

Author(s): Mwakikunga A, Hosie MJ

Publication type: Article

Publication status: Published

Journal: Cell and Tissue Research

Year: 2016

Volume: 364

Issue: 1

Pages: 209-217

Print publication date: 01/04/2016

Online publication date: 15/05/2015

Acceptance date: 23/03/2015

ISSN (print): 0302-766X

ISSN (electronic): 1432-0878

Publisher: Springer Berlin Heidelberg

URL: http://dx.doi.org/10.1007/s00441-015-2180-1

DOI: 10.1007/s00441-015-2180-1

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