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Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study

Lookup NU author(s): Professor Andrew BlamireORCiD, Dr Jiabao He, Dr Benjamin Aribisala, Professor John O'Brien



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Quantitative MRI provides important information about tissue properties in brain both in normal ageing and in degenerative disorders. Although it is well known that those with Alzheimer's disease (AD) show a specific pattern and faster rate of atrophy than controls, the precise spatial and temporal patterns of quantitative MRI in AD are unknown. We aimed to investigate neuroimaging correlates of AD using serial quantitative MRI. In our study, twenty-one subjects with AD and thirty-two similar-aged healthy controls underwent two serial MRI scans at baseline and 12 months. Tissue characteristics were captured using two quantitative MRI parameters: longitudinal relaxation time (qT1) and transverse relaxation time (qT2). The two groups (AD and controls) were statistically compared using a voxel based quantification (VBQ) method based on Matlab and SPM8. At baseline, subjects with AD showed a significant reduction of qT1 and qT2 compared to controls in bilateral temporal and parietal lobes, hippocampus, and basal ganglia. This pattern was also observed at follow-up. Longitudinally, in AD we found a significant increase rather than further reduction of qT1 and qT2 from the baseline in bilateral hippocampus, thalamus and right caudate nucleus. In addition, the longitudinal change of qT1 in left hippocampus was negatively correlated with cognitive decline in AD over the 1-year period, and the general disease severity significantly predicted the amount of increase of qT1 in bilateral hippocampus over 12 months. The longitudinal change of qT2 in left parahippocampus correlated with change in neuropsychiatric features over time. In summary, quantitative MRI parameters were reduced in AD cross-sectionally, but increased over time, showing distinct spatiotemporal patterns from the atrophy in AD. We also showed the clinical relevance of quantitative MRI parameters, indicating their potential promise as new imaging markers in AD.

Publication metadata

Author(s): Su L, Blamire AM, Watson R, He JB, Aribisala B, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Current Alzheimer Research

Year: 2016

Volume: 13

Issue: 5

Pages: 534-544

Print publication date: 01/05/2016

Acceptance date: 02/04/2016

Date deposited: 03/06/2016

ISSN (print): 1567-2050

ISSN (electronic): 1875-5828

Publisher: Bentham Science Publishers Ltd.


DOI: 10.2174/1567205013666151116141416


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Funder referenceFunder name
National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre and the Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust
NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Newcastle University
05/JTASir Jules Thorn Charitable Trust