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Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Lookup NU author(s): Professor John IsaacsORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


AIM: A genetic variant has recently reached genome-wide significance for association with TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication study in a UK Caucasian population to test for association with TNF-inhibitor response. MATERIALS & METHODS: The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures. RESULTS: Genotype data were available from 1750 TNF-inhibitor treated individuals. However, no evidence for association was observed (EULAR: p = 0.91 and DeltaDAS28: p = 0.93). Furthermore, no significant associations were observed upon stratification by the anti-TNF received (p > 0.05). CONCLUSION: In the largest replication cohort conducted to date, no evidence for association was observed.

Publication metadata

Author(s): Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Barton A

Publication type: Article

Publication status: Published

Journal: Pharmacogenomics

Year: 2016

Volume: 17

Issue: 7

Pages: 715-720

Online publication date: 18/05/2016

Acceptance date: 06/03/2016

Date deposited: 27/06/2016

ISSN (print): 1462-2416

ISSN (electronic): 1744-8042

Publisher: Future Medicine Ltd.


DOI: 10.2217/pgs.16.16

PubMed id: 27180831


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Funder referenceFunder name
Leeds Musculoskeletal Biomedical Research Unit
Newcastle's Biomedical Research Centre
NIHR's Manchester Musculoskeletal Biomedical Research Unit
20385Arthritis Research
MR/K015346/1MRC/Arthritis Research UK stratified medicine award (MATURA)