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Multigenerational Positive Family History of Psychiatric Disorders Is Associated With a Poor Prognosis in Bipolar Disorder

Lookup NU author(s): Professor Heinz Grunze

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Abstract

The authors assessed how family history loading affected the course of illness in patients from the United States. A total of 676 outpatients with bipolar disorder from the United States rated their illness and provided a parental and grandparental history of mood disorder, substance abuse, and other clinical conditions. A positive family history for each illness was associated with almost all of the seven poor prognosis factors established in the study (abuse in childhood, early onset, anxiety and substance abuse comorbidity, rapid cycling, multiple episodes, and worsening of severity or frequency of episodes). Family history for psychiatric difficulties in parents and grandparents was associated with a more complex and difficult course of bipolar illness.

Publication metadata

Author(s): Post RM, Altshuler L, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE, Leverich GS, Nolen WA

Publication type: Article

Publication status: Published

Journal: Journal of Neuropsychiatry and Clinical Neurosciences

Year: 2015

Volume: 27

Issue: 4

Pages: 304-310

Online publication date: 10/08/2015

Acceptance date: 02/01/2015

ISSN (print): 0895-0172

ISSN (electronic): 1545-7222

Publisher: American Psychiatric Publishing, Inc.

URL: http://dx.doi.org/10.1176/appi.neuropsych.14080204

DOI: 10.1176/appi.neuropsych.14080204

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