Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Assessing corneal biomechanics with Brillouin spectro-microscopy

Lookup NU author(s): Dr Ricardo Martins GouveiaORCiD, Dr Ana Gouveia Gil, Professor Che ConnonORCiD

Downloads

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

A new Brillouin spectro-microscope was designed and built to investigate the mechanical properties of bovine and human corneas. This instrument integrates a single-stage virtually imaged phased array spectrometer with a novel adaptive-optics interferometric filter to achieve unprecedented rejection of the elastic background signal. As a result, highly-resolved, reproducible data from both thin and thick collagen-based materials were obtained. In particular, this technique is capable of rigorously measuring the relative stiffness of different areas of human corneas, thus providing a true non-contact method to characterise the fundamental mechanical features of both live and fixed biological tissue samples.

Publication metadata

Author(s): Lepert G, Gouveia RM, Connon CJ, Paterson C

Publication type: Article

Publication status: Published

Journal: Faraday Discussions

Year: 2016

Volume: 187

Pages: 415-428

Print publication date: 01/06/2016

Online publication date: 06/04/2016

Acceptance date: 07/12/2015

Date deposited: 24/06/2016

ISSN (print): 1359-6640

ISSN (electronic): 1364-5498

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/C5FD00152H

DOI: 10.1039/C5FD00152H

Altmetrics

Altmetrics provided by Altmetric

Share