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Bayesian phylogenetics using an RNA substitution model applied to early mammalian evolution

Lookup NU author(s): Dr Howsun Jow


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We study the phylogeny of the placental mammals using molecular data from all mitochondrial tRNAs and rRNAs of 54 species. We use probabilistic substitution models specific to evolution in base paired regions of RNA. A number of these models have been implemented in a new phylogenetic inference software package for carrying out maximum likelihood and Bayesian phylogenetic inferences. We describe our Bayesian phylogenetic method which uses a Markov chain Monte Carlo algorithm to provide samples from the posterior distribution of tree topologies. Our results show support for four primary mammalian clades, in agreement with recent studies of much larger data sets mainly comprising nuclear DNA. We discuss some issues arising when using Bayesian techniques on RNA sequence data.

Publication metadata

Author(s): Jow H; Hudelot C; Rattray M; Higgs P

Publication type: Article

Publication status: Published

Journal: Molecular Biology and Evolution

Year: 2002

Volume: 19

Issue: 9

Pages: 1591-1601

ISSN (print): 0737-4038

ISSN (electronic): 1537-1719

Publisher: Oxford University Press