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Lookup NU author(s): Dr Daniel ColeORCiD
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Constrained geometric simulations have been performed for the recently published closed-channel state of the nicotinic acetylcholine receptor. These simulations support the theory that correlated motion in the flexible β-sheet structure of the extracellular domain helps to communicate a “conformational wave”, spreading from the acetylcholine binding pocket. Furthermore, we have identified key residues that act at the interface between subunits and between domains that could potentially facilitate rapid communication between the binding site and the transmembrane gate.
Author(s): Belfield WJ, Cole DJ, Martin IL, Payne MC, Chau P-L
Publication type: Article
Publication status: Published
Journal: Journal of Molecular Graphics and Modelling
Online publication date: 06/06/2014
Acceptance date: 02/05/2014
ISSN (print): 10933263
ISSN (electronic): 18734243
Publisher: Elsevier Inc.
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