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Fluorescence imaging in genipin crosslinked chitosan–poly(vinyl pyrrolidone) hydrogels

Lookup NU author(s): Dr Katarina Novakovic



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Recent research has identified genipin as a promising natural crosslinking agent for biocompatible hydrogels as genipin is significantly less cytotoxic than current synthetic crosslinking agents such as glutaraldehyde. Conveniently, fluorophores can be produced when genipin crosslinks. In this study, fluorescence intensity measurements of genipin crosslinked chitosan-poly(vinyl pyrrolidone) hydrogels have been explored as a dynamic, in situ method, for tracing sol-gel transition. These pH responsive smart materials have a future in medical applications, in particular in tissue engineering and drug delivery, where methods to follow the process in situ and in real time are crucial for future advancement. Samples were prepared using deionised water, pH 4 and pH 10 solutions and studied at 24 and 37

Publication metadata

Author(s): Matcham S, Novakovic K

Publication type: Article

Publication status: Published

Journal: Polymers

Year: 2016

Volume: 8

Issue: 11

Online publication date: 28/10/2016

Acceptance date: 26/10/2016

Date deposited: 26/10/2016

ISSN (electronic): 2073-4360

Publisher: MDPI AG


DOI: 10.3390/polym8110385


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Funder referenceFunder name
School of Chemical Engineering and Advanced Materials, Newcastle University
EP/H003908/1UK Engineering and Physical Sciences Research Council (EPSRC)