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Lookup NU author(s): Dr Bernhard Kepplinger, Hadiza Isah, Dr Mike ProbertORCiD, Emeritus Professor Bill CleggORCiD, Dr Corinne Wills, Professor Michael Goodfellow, Professor Jeff Errington FRSORCiD, Dr Nicholas Allenby, Dr Michael HallORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM). In DEM20745, 17-O-DMG is the major ansamycin product observed reaching a maximum titre of 17 mg/L in the fermentation broth. 17-O-DMG has significant potential for direct use in anticancer therapy and is a key starting material for the semi-synthesis of GDM analogues. This preferential biosynthesis of 17-O-DMG facilitates easy access to this important molecule and provides further insight the biosynthesis of the geldanamycins.
Author(s): Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ
Publication type: Article
Publication status: Published
Journal: Natural Product Research
Year: 2017
Volume: 31
Issue: 16
Pages: 1895-1900
Online publication date: 14/12/2016
Acceptance date: 05/11/2016
Date deposited: 25/11/2016
ISSN (print): 1478-6419
ISSN (electronic): 1478-6427
Publisher: Taylor & Francis
URL: http://dx.doi.org/10.1080/14786419.2016.1263854
DOI: 10.1080/14786419.2016.1263854
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