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Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745

Lookup NU author(s): Dr Bernhard Kepplinger, Hadiza Isah, Professor Mike ProbertORCiD, Emeritus Professor Bill CleggORCiD, Dr Corinne Wills, Professor Michael Goodfellow, Professor Jeff ErringtonORCiD, Dr Nicholas Allenby, Dr Michael HallORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM). In DEM20745, 17-O-DMG is the major ansamycin product observed reaching a maximum titre of 17 mg/L in the fermentation broth. 17-O-DMG has significant potential for direct use in anticancer therapy and is a key starting material for the semi-synthesis of GDM analogues. This preferential biosynthesis of 17-O-DMG facilitates easy access to this important molecule and provides further insight the biosynthesis of the geldanamycins.

Publication metadata

Author(s): Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ

Publication type: Article

Publication status: Published

Journal: Natural Product Research

Year: 2017

Volume: 31

Issue: 16

Pages: 1895-1900

Online publication date: 14/12/2016

Acceptance date: 05/11/2016

Date deposited: 25/11/2016

ISSN (print): 1478-6419

ISSN (electronic): 1478-6427

Publisher: Taylor & Francis


DOI: 10.1080/14786419.2016.1263854


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Funder referenceFunder name
EP/G037620/1Alcyomics Ltd
EP/G037620/1BOC Group Limited