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Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

Lookup NU author(s): Dr Phillip Lord, Dr Rachel Spiering, Dr Amy AndersonORCiD, Julie Diboll, Emeritus Professor Lindsay MarshallORCiD, Dr Rachel Harry, Professor John IsaacsORCiD, Professor Catharien Hilkens



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.

Publication metadata

Author(s): Lord P, Spiering R, Aguillón JC, Anderson AE, Appel S, Benitez-Ribas D, ten-Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van-Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van-Kooten C, López-Díaz-de-Cerio A, Nikolic T, Barbaros-Oral H, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres E, Hilkens CM

Publication type: Article

Publication status: Published

Journal: PeerJ

Year: 2016

Volume: 4

Pages: 1-14

Print publication date: 30/08/2016

Online publication date: 30/08/2016

Acceptance date: 06/07/2016

Date deposited: 30/08/2016

ISSN (electronic): 2167-8359

Publisher: PeerJ, Ltd.


DOI: 10.7717/peerj.2300


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Funder referenceFunder name
BM1305European Cooperation in Science and Technology (COST)