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Lookup NU author(s): Dr Phillip Lord,
Dr Rachel Spiering,
Dr Amy AndersonORCiD,
Emeritus Professor Lindsay MarshallORCiD,
Dr Rachel Harry,
Professor John IsaacsORCiD,
Professor Catharien Hilkens
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.
Author(s): Lord P, Spiering R, Aguillón JC, Anderson AE, Appel S, Benitez-Ribas D, ten-Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van-Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van-Kooten C, López-Díaz-de-Cerio A, Nikolic T, Barbaros-Oral H, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres E, Hilkens CM
Publication type: Article
Publication status: Published
Print publication date: 30/08/2016
Online publication date: 30/08/2016
Acceptance date: 06/07/2016
Date deposited: 30/08/2016
ISSN (electronic): 2167-8359
Publisher: PeerJ, Ltd.
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