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Expanding Our Understanding of mtDNA Deletions

Lookup NU author(s): Dr Martin Picard, Dr Amy VincentORCiD, Emeritus Professor Doug Turnbull


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Clonal expansion of mtDNA deletions compromises mitochondrial function in human disease and aging, but how deleterious mtDNA genomes propagate has remained unclear. In this issue (Gitschlag et al., 2016) and in a recent Nature publication, C. elegans studies implicate the mitochondrial unfolded protein response (UPRmt) and offer mechanistic insights into this process.

Publication metadata

Author(s): Picard M, Vincent AE, Turnbull DM

Publication type: Editorial

Publication status: Published

Journal: Cell Metabolism

Year: 2016

Volume: 24

Issue: 1

Pages: 3-4

Online publication date: 12/07/2016

Acceptance date: 01/01/1900

ISSN (print): 1550-4131

ISSN (electronic): 1932-7420

Publisher: Cell Press


DOI: 10.1016/j.cmet.2016.06.024