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Do Cortical Circuits Need Protecting from Themselves?

Lookup NU author(s): Professor Andrew Trevelyan


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All hippocampal and neocortical networks can be driven to seize quite easily. This can be done using drugs, by altering the ionic constituency of the bathing medium [cerebrospinal fluid (CSF)], or by electrical stimulation (both experimentally and clinically, as in electroconvulsive therapy). It is worth asking why this is so, because this will both tell us more about potentially devastating neurological disorders and extend our understanding of cortical function and architecture. Here I review work examining the features of cortical networks that bias activity towards and away from hyperexcitability. I suggest that several cellular- and circuit-level features of rapidly responsive interneuron networks tip the balance away from seizure in the healthy brain.

Publication metadata

Author(s): Trevelyan AJ

Publication type: Review

Publication status: Published

Journal: Trends in Neuroscience

Year: 2016

Volume: 39

Issue: 8

Pages: 502-511

Print publication date: 01/08/2016

Online publication date: 01/07/2016

Acceptance date: 01/01/1900

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X



DOI: 10.1016/j.tins.2016.06.002