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Wnt Signaling in Heart Organogenesis

Lookup NU author(s): Dr Silvia Mazzotta


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Understanding heart development is of fundamental importance, because the heart organ is the first functional organ in mammalian embryos and heart function is unremittingly required throughout subsequent life. Earlier cultured stem cell experiments highlighted positive effects of canonical Wnt signaling on subsequent cardiomyocyte differentiation. An early function for Wnt/β-catenin signaling relates to its requirement for mesoderm induction from which cardiac tissue subsequently differentiates. Noncanonical Wnt signaling is clearly a strong stimulator of cardiac specification and subsequent cardiomyocyte differentiation. It has been shown that this effect is mediated by the Wnt/JNK signaling pathway. Translational medicine more recently has focused on the possible lessons to be learned from Wnt signaling mechanisms in embryonic heart development for regeneration of injured heart muscle, for instance, after myocardial infarction.

Publication metadata

Author(s): Hoppler S, Mazzotta S, Kuhl M

Editor(s): Hoppler, S; Moon, RT

Publication type: Book Chapter

Publication status: Published

Book Title: Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

Year: 2014

Print publication date: 05/05/2014

Online publication date: 07/03/2014

Acceptance date: 07/03/2014

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1002/9781118444122.ch22

Library holdings: Search Newcastle University Library for this item

ISBN: 9781118444160