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Lookup NU author(s): Dr Daniel Rico RodriguezORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs.
Author(s): Juan D, Perner D, Carrillo de Santa Pau E, Marsili S, Ochoa D, Chung HR, Vingron M, Rico D, Valencia A
Publication type: Article
Publication status: Published
Journal: Cell Reports
Print publication date: 09/02/2016
Online publication date: 28/01/2016
Acceptance date: 29/12/2015
Date deposited: 31/10/2016
ISSN (print): 2211-1247
Publisher: Cell Press
PubMed id: 26832418
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