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Incidence, characteristics and course of narrow phenotype paediatric bipolar I disorder in the British Isles

Lookup NU author(s): Dr Aditya SharmaORCiD, Dr Joanne Neely, Dr Nigel Camilleri, Professor Heinz Grunze, Professor Ann Le Couteur



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley-Blackwell Publishing, Inc., 2016.

For re-use rights please refer to the publisher's terms and conditions.


Objective: To estimate the surveillance incidence of first-time diagnosis of narrow phenotype bipolar I disorder (NPBDI) in young people under 16 years by consultants in child and adolescent psychiatry(CCAP) in the British Isles and describe symptoms, comorbidity, associated factors, management strategies and clinical outcomes at 1-year follow-up. Method: Active prospective surveillance epidemiology was utilised to ask 730 CCAP to report cases of NPBDI using the child and adolescent psychiatry surveillance system. Results: Of the 151 cases of NPBDI reported, 33 (age range 10–15.11 years) met the DSM-IV analytical case definition with 60% having had previously undiagnosed mood episodes. The minimum 12-month incidence of NPBDI in the British Isles was 0.59/100 000 (95% CI 0.41–0.84). Irritability was reported in 72% cases and comorbid conditions in 51.5% cases with 48.5% cases requiring admission to hospital. Relapses occurred in 56.67% cases during the 1-year follow-up. Conclusions: These rates suggest that the first-time diagnosis of NPBDI in young people <16 years of age by CCAP in the British Isles is infrequent; however, the rates of relapse and admission to hospital warrant close monitoring.

Publication metadata

Author(s): Sharma A, Neely J, Camilleri N, James A, Grunze H, Le Couteur A

Publication type: Article

Publication status: Published

Journal: Acta Psychiatrica Scandinavica

Year: 2016

Volume: 134

Issue: 6

Pages: 522-532

Print publication date: 01/12/2016

Online publication date: 15/10/2016

Acceptance date: 19/09/2016

Date deposited: 11/11/2016

ISSN (print): 0001-690X

ISSN (electronic): 1600-0447

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/acps.12657


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