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Lookup NU author(s): Professor Farhad Kamali
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We aimed to assess the cost-effectiveness of pharmacogenetic-guided dosing of warfarin in patients with atrial fibrillation (AF) in the United Kingdom and Sweden. Data from EU-PACT, a randomized controlled trial in newly diagnosed AF patients, were used to model the incremental costs per quality-adjusted life-year (QALY) gained by pharmacogenetic-guided warfarin dosing versus standard treatment over a lifetime horizon. Incremental lifetime costs were 26 and 382 Swedish kronor (SEK) and incremental QALYs were 0.0039 and 0.0015 in the United Kingdom and Sweden, respectively. The corresponding incremental cost-effectiveness ratios (ICERs) were 6 702 and 253 848 SEK per QALY gained. The ICER was below the willingness-to-pay threshold of 20 000 per QALY gained in 93% of the simulations in the United Kingdom and below 500 000 SEK in 67% of the simulations in Sweden. Our data suggest that pharmacogenetic-guided dosing of warfarin is a cost-effective strategy to improve outcomes of patients with AF treated with warfarin in the United Kingdom and in Sweden.
Author(s): Verhoef TI, Redekop WK, Langenskiold S, Kamali F, Wadelius M, Burnside G, Maitland-van der Zee AH, Hughes DA, Pirmohamed M
Publication type: Article
Publication status: Published
Journal: Pharmacogenomics Journal
Print publication date: 01/10/2016
Online publication date: 07/06/2016
Acceptance date: 02/05/2016
ISSN (print): 1470-269X
ISSN (electronic): 1473-1150
Publisher: Nature Publishing Group
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