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Reply to "Liver Failure in Human Immunodeficiency Virus - Hepatitis C Virus Coinfection Treated with Sofosbuvir, Ledipasvir and Antiretroviral Therapy"

Lookup NU author(s): Dr Jess Dyson, Professor Stuart McPhersonORCiD


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We would like to thank Marchan-Lopez et al. for their letter following our recently published article [1]. They report another case of liver injury related to treatment with sofosbuvir and a NS5A inhibitor (ledipasvir) in a patient with hepatitis C and HIV coinfection. In both cases we described hepatic decompensation occurred within 3 weeks of commencing the antiviral therapy. It is interesting to note that their patient did not decompensate until 2 months after commencing therapy with the DAAs and also had symptoms of abdominal pain and vomiting with no alternative explanation.

Publication metadata

Author(s): Dyson JK, McPherson S

Publication type: Article

Publication status: Published

Journal: Journal of Hepatology

Year: 2016

Volume: 64

Issue: 3

Pages: 753-754

Print publication date: 01/03/2016

Online publication date: 10/12/2015

Acceptance date: 01/01/1900

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641

Publisher: Elsevier


DOI: 10.1016/j.jhep.2015.11.038


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