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Pregnancy in cardiac transplant recipients

Lookup NU author(s): Dr Guy MacGowanORCiD, Dr Gareth Parry


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Purpose: Successful pregnancy following cardiac transplantation has been described, although outcome data from individual centers are relatively sparse. We investigated maternal and fetal outcomes including change in left ventricular (LV) function and calcineurin inhibitor (CNI) dose in women who became pregnant from our institution.Methods: We identified every female patient <49 years at the time of transplant who survived >3 months post surgery, between 1985 and 2014. Those who conceived had a review of their medical records and transplant charts. Those currently alive were interviewed.Results: There were 22 pregnancies in 17 women with 20 live births (91%). Mean time from transplantation was 98 +/- 62.4 months. Rejection complicated one pregnancy, and LV function remained normal in all others. Hypertension complicated 3 (13.6%), pre-eclampsia 3 (13.6%), and cholestasis 1 (4.5%). Mean birthweight was 2447 +/- 608 grams at 34.1 +/- 3.6 weeks. Four women died following pregnancy. A significant increase in total daily dose of tacrolimus and cyclosporine A was required to maintain therapeutic levels through pregnancy (CyA, P<.001; and Tac, P=.001), with no deterioration in serum creatinine.Conclusions: We report a 91% live birth rate post cardiac transplantation. Meticulous individualized care with frequent monitoring of CNI levels and LV function is necessary to optimize the maternal and fetal outcomes.

Publication metadata

Author(s): Bhagra CJ, Bhagra SK, Donado A, Butt T, Forrest L, MacGowan GA, Parry G

Publication type: Article

Publication status: Published

Journal: Clinical Transplantation

Year: 2016

Volume: 30

Issue: 9

Pages: 1059-1065

Print publication date: 01/09/2016

Online publication date: 25/07/2016

Acceptance date: 14/06/2016

ISSN (print): 0902-0063

ISSN (electronic): 1399-0012

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/ctr.12788


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