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Glycopeptide resistance: links with inorganic phosphate metabolism and cell envelope stress

Lookup NU author(s): Dr Fernando Santos Beneit

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Abstract

Antimicrobial resistance is a critical health issue today. Many pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Glycopeptides are used as a 'last resort' antibiotic treatment for many bacterial infections, but worryingly, glycopeptide resistance has spread to very important pathogens such as Enterococcus faecium and Staphylococcus aureus. Bacteria confront multiple stresses in their natural environments, including nutritional starvation and the action of cell-wall stressing agents. These stresses impact bacterial susceptibility to different antimicrobials. This article aims to review the links between glycopeptide resistance and different stresses, especially those related with cell-wall biosynthesis and inorganic phosphate metabolism, and to discuss promising alternatives to classical antibiotics to avoid the problem of antimicrobial resistance.

Publication metadata

Author(s): Santos-Beneit F, Ordóñez-Robles M, Martín JF

Publication type: Article

Publication status: Published

Journal: Biochemical Pharmacology

Year: 2017

Volume: 133

Pages: 74-85

Print publication date: 01/06/2017

Online publication date: 25/11/2016

Acceptance date: 15/11/2016

Date deposited: 06/02/2017

ISSN (print): 0006-2952

ISSN (electronic): 1873-2968

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.bcp.2016.11.017

DOI: 10.1016/j.bcp.2016.11.017

PubMed id: 27894856

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