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Lookup NU author(s): Cyril Eleftheriou, Dr Henrik Kjeldsen, Professor Evelyne SernagorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The choice of electrode material is of paramount importance in neural prosthetic devices. Electrodes must be biocompatible yet able to sustain repetitive current injections in a highly corrosive environment. We explored the suitability of carbon nanotube (CNT) electrodes to stimulate retinal ganglion cells (RGCs) in a mouse model of outer retinal degeneration. We investigated morphological changes at the bio-hybrid interface and changes in RGC responses to electrical stimulation following prolonged in vitro coupling to CNT electrodes.We observed gradual remodelling of the inner retina to incorporate CNT assemblies. Electrophysiological recordings demonstrate a progressive increase in coupling between RGCs and the CNT electrodes over three days, characterized by a gradual decrease in stimulation thresholds and increase in cellular recruitment. These results provide novel evidence for time-dependent formation of viable bio-hybrids between CNTs and the retina, demonstrating that CNTs are a promising material for inclusion in retinal prosthetic devices. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Author(s): Eleftheriou CG, Zimmermann JB, Kjeldsen HD, David-Pur M, Hanein Y, Sernagor E
Publication type: Article
Publication status: Published
Journal: Biomaterials
Year: 2017
Volume: 112
Pages: 108-121
Print publication date: 01/01/2017
Online publication date: 11/10/2016
Acceptance date: 11/10/2016
Date deposited: 16/01/2017
ISSN (print): 0142-9612
ISSN (electronic): 1878-5905
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.biomaterials.2016.10.018
DOI: 10.1016/j.biomaterials.2016.10.018
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