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Validation of a questionnaire for orthostatic hypotension for routine clinical use

Lookup NU author(s): Dr James FrithORCiD, Emerita Professor Julia Newton


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Aim: To validate a new patient-reported outcome measure for routine clinical use.Methods: A total of 50 older individuals with orthostatic hypotension who attended a falls and syncope clinic completed three questionnaires, the recently developed Orthostatic Hypotension Questionnaire, the existing Orthostatic Grading Scale and the quality of life measure EQ-5D-5L. Validity of the Orthostatic Hypotension Questionnaire was tested against the aforementioned questionnaires for symptoms and for quality of life. Comorbidity was quantified using the Charlson Comorbidity Index.Results: The cohort of 50 individuals had a median age of 67 years (interquartile range 26-89 years) with a median Charlson Comorbidity Index of 3 (interquartile range 2-5). The total Orthostatic Hypotension Questionnaire Symptom Assessment score correlated strongly with the Orthostatic Grading Scale (0.616, P<0.001) and the Orthostatic Hypotension Questionnaire Daily Activity Scale correlated strongly with daily activity on the EQ-5D-5L (0.61, P<0.001). Using the Orthostatic Grading Scale, individuals' symptoms were categorized as mild, moderate or severe, the Orthostatic Hypotension Questionnaire scores were significantly different between these groups (P<0.001). Internal consistency was high (Cronbach's apha 0.882), and ceiling or floor effects did not limit the total scores.Conclusion: The Orthostatic Hypotension Questionnaire is a valid patient report tool to quantify the symptom burden of people with orthostatic hypotension. Because the symptoms associated with orthostatic hypotension are frequently non-specific, it will be a clinically useful tool to measure and quantify symptom load in people with orthostatic hypotension.

Publication metadata

Author(s): Frith J, Newton JL

Publication type: Article

Publication status: Published

Journal: Geriatrics & Gerontology International

Year: 2016

Volume: 16

Issue: 7

Pages: 785-790

Print publication date: 14/07/2016

Online publication date: 14/07/2015

Acceptance date: 14/05/2015

ISSN (print): 1444-1586

ISSN (electronic): 1447-0594

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/ggi.12553


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Funder referenceFunder name
CS-2014-14-002Department of Health