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Lookup NU author(s): Emeritus Professor Bill Clegg
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Using a specially designed magnesium metallating manifold, combining kinetically activated TMP amide base with a sterically amplified β-diketiminate ligand, this study has established a new regioselective strategy for magnesiation of challenging N-heterocyclic molecules. The broad scope of the approach is illustrated through reactions of pyrazine, triazoles and substituted pyridines by isolation and structural elucidation of their magnesiated intermediates.
Author(s): Davin L, McLellan R, Hernan-Gomez A, Clegg W, Kennedy AR, Mertens M, Stepek IA, Hevia E
Publication type: Article
Publication status: Published
Journal: Chemical Communications
Print publication date: 04/04/2017
Online publication date: 09/01/2017
Acceptance date: 05/01/2017
Date deposited: 16/01/2017
ISSN (print): 1359-7345
ISSN (electronic): 1364-548X
Publisher: Royal Society of Chemistry
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