Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Regioselective magnesiation of N-heterocyclic molecules: securing insecure cyclic anions by a β-diketiminate-magnesium clamp

Lookup NU author(s): Professor William Clegg

Downloads

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

Using a specially designed magnesium metallating manifold, combining kinetically activated TMP amide base with a sterically amplified β-diketiminate ligand, this study has established a new regioselective strategy for magnesiation of challenging N-heterocyclic molecules. The broad scope of the approach is illustrated through reactions of pyrazine, triazoles and substituted pyridines by isolation and structural elucidation of their magnesiated intermediates.

Publication metadata

Author(s): Davin L, McLellan R, Hernan-Gomez A, Clegg W, Kennedy AR, Mertens M, Stepek IA, Hevia E

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2017

Volume: 53

Issue: 26

Pages: 3653-3656

Print publication date: 04/04/2017

Online publication date: 09/01/2017

Acceptance date: 05/01/2017

Date deposited: 16/01/2017

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/C6CC09675A

DOI: 10.1039/C6CC09675A

Altmetrics

Altmetrics provided by Altmetric

Share