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Lookup NU author(s): Dr Hannah Sinclair,
Dr Murugu Veerasamy,
Dr Mohaned Egred,
Professor Vijay KunadianORCiD
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Markers of coronary plaque vulnerability, such as a high lipid burden, increased inflammatory activity, and a thin fibrous cap, have been identified in histological studies. In vivo, grayscale intravascular ultrasound (IVUS) provides more in-depth information on coronary artery plaque burden than conventional angiography but is unable to accurately distinguish between noncalcific tissue types within the plaque. An analysis of IVUS radiofrequency backscatter based on spectral pattern recognition, such as virtual histology IVUS, allows detailed scrutiny of plaque composition and classification of coronary lesions. This review discusses the virtual histology IVUS technology and its accuracy in identifying vulnerable plaque features, focusing on its use in predicting patient outcomes after acute coronary syndrome, and its limitations in clinical practice.
Author(s): Sinclair H, Veerasamy M, Bourantas C, Egred M, Nair A, Calvert PA, Brugaletta S, Mintz GS, Kunadian V
Publication type: Review
Publication status: Published
Journal: Cardiology in Review
Print publication date: 01/11/2016
Acceptance date: 01/01/1900
ISSN (print): 1061-5377
ISSN (electronic): 1538-4683
Publisher: LIPPINCOTT WILLIAMS & WILKINS