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Fractional diffusion as a probe of microstructural change in a mouse model of Duchenne muscular dystrophy

Lookup NU author(s): Dr Paola Porcari, Professor Andrew BlamireORCiD


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We apply a fractional diffusion model to preclinical data from a mouse model of Duchenne Muscular Dystrophy, and compare to histological measurements of the underlying tissue. We find that the alpha exponent of the model provides contrast which is indicative of the microstructural changes associated with DMD. We observe contrast between the wild type and mdx mouse model.

Publication metadata

Author(s): Hall MG, Porcari P, Blamire AM, Clark CA

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: ISMRM 24th Annual Scientific Meeting & Exhibition

Year of Conference: 2016

Pages: 1981

Print publication date: 16/05/2016

Online publication date: 07/05/2015

Acceptance date: 04/02/2016

Publisher: International Society for Magnetic Resonance in Medicine