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Lookup NU author(s): Dr Paola Porcari,
Professor Volker StraubORCiD,
Professor Andrew BlamireORCiD
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In this study, we investigated whether diffusion MRI might be a useful method to evaluate differences in the microarchitecture of hindlimb muscles between dystrophic (mdx) and healthy (wt) mice of three groups of age. Mice were investigated at multiple diffusion times and significant differences between the diffusion properties of hindlimb muscles in healthy and diseased mice were found for long diffusion times. High specificity and sensitivity of the method was demonstrated and also confirmed by the preliminary results of the histological assessment, thus suggesting a powerful and straightforward application on humans.
Author(s): Porcari P, Greally E, Straub V, Blamire AM
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: ISMRM 23rd Annual Scientific Meeting & Exhibition
Year of Conference: 2015
Print publication date: 08/06/2015
Online publication date: 01/06/2015
Acceptance date: 05/02/2015
Publisher: International Society for Magnetic Resonance in Medicine
Notes: ISMRM MAGNA cum LAUDE Merit Award. Abstract #0252.