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In vivo diffusion MR study at 7T of hindlimb muscles in a mouse model of Duchenne muscular dystrophy

Lookup NU author(s): Dr Paola Porcari, Liz Greally, Professor Volker StraubORCiD, Professor Andrew BlamireORCiD

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Abstract

In this study, we investigated whether diffusion MRI might be a useful method to evaluate differences in the microarchitecture of hindlimb muscles between dystrophic (mdx) and healthy (wt) mice of three groups of age. Mice were investigated at multiple diffusion times and significant differences between the diffusion properties of hindlimb muscles in healthy and diseased mice were found for long diffusion times. High specificity and sensitivity of the method was demonstrated and also confirmed by the preliminary results of the histological assessment, thus suggesting a powerful and straightforward application on humans.

Publication metadata

Author(s): Porcari P, Greally E, Straub V, Blamire AM

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: ISMRM 23rd Annual Scientific Meeting & Exhibition

Year of Conference: 2015

Pages: 252

Print publication date: 08/06/2015

Online publication date: 01/06/2015

Acceptance date: 05/02/2015

Publisher: International Society for Magnetic Resonance in Medicine

URL: http://dev.ismrm.org/2015/0252.html

Notes: ISMRM MAGNA cum LAUDE Merit Award. Abstract #0252.

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