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C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection

Lookup NU author(s): Dr Tevfik Dorak

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Abstract

We explored the influence of the major CCR5 promoter or coding region variants as haplotypes and genotypes in a cohort of 250 chronically infected HCV patients receiving combined interferon/ ribavirin therapy. No haplotype, including the D32-bearing haplotype (G*2) reportedly associated in homozygotes with high HCV viral load (VL), showed a similar effect. Patients with genotype C/G*2 showed slightly lower median VL (p = 0.05). Neither the G*2 haplotype nor the C/G*2 genotype influenced viral dynamics during the initial 12 wk of treatment (p = 0.53). The genotype E/E was more frequent among sustained responders (15.5%) than non-responders (7.8%), and VL declined further among E/E homozygotes during the initial 12 wk of treatment, particularly those with HCV genotype 1 (p = 0.016). Differential receptor expression due to E/E homozygosity in HCV infection remains to be confirmed.

Publication metadata

Author(s): Dorak MT; Folayan GO; Niwas S; van Leeuwen DJ; Yee LJ; Tang J; Kaslow RA

Publication type: Article

Publication status: Published

Journal: Immunologic Research

Year: 2002

Volume: 26

Issue: 1-3

Pages: 167-175

ISSN (print): 0257-277X

ISSN (electronic): 1559-0755

Publisher: Humana Press, Inc.

URL: http://dx.doi.org/10.1385/IR:26:1-3:167

DOI: 10.1385/IR:26:1-3:167

PubMed id: 12403355

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