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New Approaches to Investigate Drug-Induced Hypersensitivity

Lookup NU author(s): Dr Shaheda Ahmed, Professor Anne Dickinson


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The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immuno-logical bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.

Publication metadata

Author(s): Ogese MO, Ahmed S, Alferivic A, Betts CJ, Dickinson A, Faulkner L, French N, Gibson A, Hirschfield GM, Kammuller M, Meng XL, Martin SF, Musette P, Norris A, Pirmohamed M, Park BK, Purcell AW, Spraggs CF, Whritenour J, Naisbitt DJ

Publication type: Article

Publication status: Published

Journal: Chemical Research in Toxicology

Year: 2017

Volume: 30

Issue: 1

Pages: 239-259

Print publication date: 17/01/2017

Online publication date: 02/11/2016

Acceptance date: 02/04/2016

ISSN (print): 0893-228X

ISSN (electronic): 1520-5010

Publisher: American Chemical Society


DOI: 10.1021/acs.chemrestox.6b00333


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Funder referenceFunder name
National Institute of Health Research Birmingham Liver Biomedical Research Unit
115336European Community under the Innovative Medicine Initiative project MIP-DILI
MR/L006758/1Medical Research Council