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Anti-arthritic effect of eugenol on collagen-induced arthritis experimental model.

Lookup NU author(s): Dr Henrique De Paula LemosORCiD


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This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in the hind paws. Treatment with eugenol starting at the onset of arthritis (day 25) ameliorated these clinical signs of CIA. Furthermore, eugenol inhibited mononuclear cell infiltration into the knee joints of arthritic mice and also lowered the levels of cytokines (tumor necrosis factor (TNF)-α, interferon (IFN)-γ and tumor growth factor (TGF)-β) within the ankle joints. Eugenol treatment did not affect the in vitro cell viability as assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Therefore, eugenol ameliorates experimental arthritis and could be useful as a beneficial supplement in treating human arthritis.

Publication metadata

Author(s): Grespan R, Paludo M, Lemos HdeP, Barbosa CP, Bersani-Amado CA, Dalalio MM, Cuman RK

Publication type: Article

Publication status: Published

Journal: Biological and Pharmaceutical Bulletins

Year: 2012

Volume: 35

Issue: 10

Pages: 1818-1820

ISSN (print): 0918-6158

ISSN (electronic): 1347-5215

Publisher: Pharmaceutical Society of Japan


DOI: 10.1248/bpb.b12-00128

PubMed id: 23037170


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