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Long-term support of patients receiving a left ventricular assist device for advanced heart failure: a follow-up analysis of the Registry to Evaluate the HeartWare Left Ventricular Assist System

Lookup NU author(s): Dr Stephan Schueler

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Abstract

OBJECTIVES: The Registry to Evaluate the HeartWare Left Ventricular Assist System (ReVOLVE) is an investigator-initiated multicentre, prospective, single-arm database established to collect post-Conformite Europeenne Mark clinical information on patients receiving the HeartWare (R) Ventricular Assist System (HVAD (R)). The number of patients requiring longer periods of mechanical circulatory support is ever increasing and so further investigation into long-term outcomes in bridge-to-transplant populations is necessary.METHODS: Data were collected on 254 commercial implants performed between February 2009 and March 2012 from nine centres in Europe (7 centres) and Australia (2 centres). Patients were followed to device explant, heart transplant or death, and the outcomes of patients who remained on support longer than 2 years were analysed. Summary statistics were used to describe patient demographics, adverse events, length of support and outcomes for this long-term cohort.RESULTS: A total of 124 patients (49% of the original ReVOLVE population) were on support for more than 2 years (range: 731-2108 days), 76 of whom are still alive on support. Overall survival through 5 years was 59%.CONCLUSIONS: Owing to the low rate of heart transplants, a significant number of patients receiving a left ventricular assist device as a bridge to transplant remain on support for prolonged periods, often exceeding 2, 3 and even 4 years. Real-world use of the HVAD system continues to show excellent outcomes for patients on the device, including those on support beyond 2 years.

Publication metadata

Author(s): Schmitto JD, Zimpfer D, Fiane AE, Larbalestier R, Tsui S, Jansz P, Simon A, Schueler S, Strueber M

Publication type: Article

Publication status: Published

Journal: European Journal of Cardio-Thoracic Surgery

Year: 2016

Volume: 50

Issue: 5

Pages: 834-838

Print publication date: 01/11/2016

Online publication date: 13/07/2016

Acceptance date: 09/04/2016

ISSN (print): 1010-7940

ISSN (electronic): 1873-734X

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ejcts/ezw224

DOI: 10.1093/ejcts/ezw224

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