Toggle Main Menu Toggle Search

Open Access padlockePrints

Age at Onset of Bipolar Disorder Related to Parental and Grandparental Illness Burden

Lookup NU author(s): Professor Heinz Grunze

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Objective: The age at onset of bipolar disorder varies greatly in different countries and continents. The association between load of family history of psychiatric illness and age at onset has not been adequately explored.Methods: 979 outpatients with bipolar disorder (from 4 sites in the United States and 3 in the Netherlands and Germany) gave informed consent and completed a questionnaire about their demographics, age at onset of illness, and family history of unipolar and bipolar disorder, alcohol and substance abuse comorbidity, suicide attempts, and "other" illnesses in their parents, 4 grandparents, and any offspring. We examined how the parental and grandparental burden of these illnesses related to the age at onset of the patients' bipolar disorder.Results: The burden of family psychiatric history was strongly related to an earlier age at onset of illness in both US and European patients (F-3,F-906 = 35.42, P<.0001). However, compared to the Europeans, patients in the United States had both more family history of most difficulties and notably earlier age at onset. Earlier age at onset was associated with a greater illness burden in the patient's offspring (t(568) = 4.1, P<.0001).Conclusions: More parental and grandparental psychiatric illness was associated with an earlier age at onset of bipolar disorder, which is earlier in the United States compared with Europe and is strongly related to a poor long-term prognosis. This apparent polygenic contribution to early onset deserves further study and therapeutic attempts at ameliorating the transgenerational impact. (C) Copyright 2016 Physicians Postgraduate Press, Inc.


Publication metadata

Author(s): Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE, Leverich GS, Nolen WA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Psychiatry

Year: 2016

Volume: 77

Issue: 10

Pages: E1309-E1315

Print publication date: 01/10/2016

Acceptance date: 02/04/2016

ISSN (print): 0160-6689

ISSN (electronic): 1555-2101

Publisher: Physicians Postgraduate Press, Inc.

URL: https://doi.org/10.4088/JCP.15m09811

DOI: 10.4088/JCP.15m09811


Altmetrics

Altmetrics provided by Altmetric


Share