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Lookup NU author(s): Dr Ingrid Ehrmann,
Professor David Elliott
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STAR (signal transduction and activation of RNA) proteins regulate splicing of target genes that have roles in neural connectivity, survival and myelination in the vertebrate nervous system. These regulated splicing targets include mRNAs such as the Neurexins (Nrxn), SMN2 (survival of motor neuron) and MAG (myelin-associated glycoprotein). Recent work has made it possible to identify and validate STAR protein splicing targets in vivo by using genetically modified mouse models. In this review, we will discuss the importance of STAR protein splicing targets in the CNS (central nervous system).
Author(s): Ehrmann I, Fort P, Elliott DJ
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 15/08/2016
Online publication date: 15/08/2016
Acceptance date: 01/01/1900
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press
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