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STARs in the CNS

Lookup NU author(s): Dr Ingrid Ehrmann, Professor David Elliott

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Abstract

STAR (signal transduction and activation of RNA) proteins regulate splicing of target genes that have roles in neural connectivity, survival and myelination in the vertebrate nervous system. These regulated splicing targets include mRNAs such as the Neurexins (Nrxn), SMN2 (survival of motor neuron) and MAG (myelin-associated glycoprotein). Recent work has made it possible to identify and validate STAR protein splicing targets in vivo by using genetically modified mouse models. In this review, we will discuss the importance of STAR protein splicing targets in the CNS (central nervous system).

Publication metadata

Author(s): Ehrmann I, Fort P, Elliott DJ

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2016

Volume: 44

Issue: 4

Pages: 1066-1072

Print publication date: 15/08/2016

Online publication date: 15/08/2016

Acceptance date: 01/01/1900

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press

URL: http://dx.doi.org/10.1042/BST20160084

DOI: 10.1042/BST20160084

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