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2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms

Lookup NU author(s): Dr John Perry

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Abstract

© 2015 Elsevier Ltd.A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.

Publication metadata

Author(s): Cellier M, Gignoux A, James AL, Orenga S, Perry JD, Robinson SN, Stanforth SP, Turnbull G

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry Letters

Year: 2015

Volume: 25

Issue: 24

Pages: 5694-5698

Print publication date: 15/12/2015

Online publication date: 02/11/2015

Acceptance date: 31/12/2015

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Elsevier Ltd

URL: http://doi.org/10.1016/j.bmcl.2015.10.099

DOI: 10.1016/j.bmcl.2015.10.099

PubMed id: 26547691

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