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Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta-analysis of English-language literature

Lookup NU author(s): Dr Michael DrinnanORCiD, Professor Vinidh Paleri


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Background The purpose of this systematic review and meta-analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer. Methods The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease-free survival (DFS), and overall survival (OS) rates were calculated. Results The pooled mean estimates were: local control rate at 24 months after first TLM (n = 249), 56.9% (95% confidence interval [CI], 47.4-66.1); local control after repeat TLM (n = 186), 63.8% (95% CI, 57.1-70.2); DFS (n = 174), 70.9% (95% CI, 60.8-80); and OS (n = 276), 74.8% (95% CI, 68.2-80.9). Pooled mean laryngeal preservation (n = 286) was 72.3% (95% CI, 68.4-76.1). Conclusion TLM is oncologically sound in the salvage setting with high larynx-preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques. Copyright © 2013 Wiley Periodicals, Inc.

Publication metadata

Author(s): Ramakrishnan Y, Drinnan M, Kwong FNK, Grant DG, Mehanna H, Jones T, Paleri V

Publication type: Article

Publication status: Published

Journal: Head and Neck

Year: 2014

Volume: 36

Issue: 2

Pages: 280-285

Print publication date: 01/02/2014

Online publication date: 14/06/2013

Acceptance date: 24/01/2013

ISSN (print): 1043-3074

ISSN (electronic): 1097-0347

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/hed.23291

PubMed id: 23766141


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