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Human leukocyte antigen-A, -B and -C alleles and human leukocyte antigen haplotypes in Turkey: relationship to other populations

Lookup NU author(s): Dr Tevfik Dorak


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In this study, we present, for the first time, human leukocyte antigen (HLA) class I allele and haplotype frequencies at the DNA level in a sample of 142 donors from Turkey. HLA typing was performed by medium-to-high resolution polymerase chain reaction sequence-specific oligonucleotide probes method. The most frequent HLA alleles at class I locus were A*0201(0.257), -B*35(0.204) and -Cw*04(0.173). A*0201-B*35-Cw*04(0.056) was the most common three-locus haplotype. Allele and haplotype frequency comparisons and neighbour-joining dendrograms, constructed using DA genetic distances and correspondence analysis using HLA-A, -B and -C, and -DRB1 allele frequencies, revealed similarities with other Mediterranean and European populations, but not with Mongol populations. These results agree with previous studies and confirm that the present day Turkish population is genetically more similar to its geographic neighbours than its historical neighbours in central Asia. The comprehensive HLA data on the Turkish population at the DNA level including up to six-locus putative haplotypes generated in this study will be useful for further studies.

Publication metadata

Author(s): Dorak MT; Uyar FA; Saruhan-Direskeneli G

Publication type: Article

Publication status: Published

Journal: Tissue Antigens

Year: 2004

Volume: 64

Issue: 2

Pages: 180-187

ISSN (print): 0001-2815

ISSN (electronic): 1399-0039

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/j.1399-0039.2004.00258.x

PubMed id: 15245373

Notes: 0001-2815 Journal Article


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