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Lookup NU author(s): Dr Simon Meggitt
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Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Here we perform a genome-wide association analysis in the United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132). In a second stage, we genotype putative-associated loci in a further 2,063 acne cases and 1,970 controls. We identify three genome-wide significant associations: 11q13.1 (rs478304, Pcombined =3.23 × 10 -11, odds ratio (OR)=1.20), 5q11.2 (rs38055, Pcombined =4.58 × 10-9, OR=1.17) and 1q41 (rs1159268, P combined =4.08 × 10-8, OR=1.17). All three loci contain genes linked to the TGFβ cell signalling pathway, namely OVOL1, FST and TGFB2. Transcripts of OVOL1 and TFGB2 have decreased expression in affected compared with normal skin. Collectively, these data support a key role for dysregulation of TGFβ-mediated signalling in susceptibility to acne. © 2014 Macmillan Publishers Limited. All rights reserved.
Author(s): Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, Willis C, Akhras V, Alexandroff A, Anstey A, Azad J, Aziz O, Baudry D, Burrows N, Butt A, Cartwright P, Chapman A, Clayton T, Cliff S, Cunliffe W, Cutler T, Daly B, Damian E, Darvay A, DeGiovanni C, Downs A, Duckworth M, Dwyer C, Ferguson A, Fleming C, Fox Z, Frazer-Andrews E, Gonzalez J, Goodfield M, Graham R, Grattan C, Green N, Hazelwood-Smith S, Hempel H, Hood S, Hughes B, Ladoyanni E, Lyon C, Mahmud A, Malik M, Meggitt S, Messenger A, Moosa Y, Ormerod A, Patel V, Rallan D, Robertson S, Ross J, Salvary I, Wachsmuth R, Wahie S, Williamson D, Deret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Publication type: Article
Publication status: Published
Journal: Nature Communications
Online publication date: 13/06/2014
Acceptance date: 01/05/2014
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
PubMed id: 24927181
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